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For example, tight junction modulators Clostridium perfringens enterotoxin (CPE) and Zonula occludens toxin (Zot) reversibly open tight junctions to facilitate paracellular drug absorption through nasal epithelia [61, 62], while the C-terminal fragment of CPE (C-CPE) disrupts tight junctions through modulation of claudins and has been used to increase absorption of human parathyroid hormone in rats [63]

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