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Glutathione and detoxification

(2012) elucidated that sciatic nerve injury induced by the CCI model not only initiates chronic neuropathic pain, but also increases the expression of caspase-3 in the spinal cord and caspase-3-dependent apoptosis of dorsal horn neurons, which is associated with up-regulation of growth associated protein 43 (GAP-43) expression

Neural cell migration is also activated by stromal cell-derived factor 1/chemokine receptor 4 (SDF-1/CXCR4) [88, 89] and neuronal cells express CXCR4, the cognate receptor for SDF-1