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10.1111/ppl.12032 [Epub ahead of print]

The gut microbiota contributes to host metabolism and protects against pathogens, thereby affecting directly or indirectly host physiological functions ( Collinsella belongs to the family Coriobacteriaceae and the phylum Actinobacteria

In line with the covalent binding mechanism, in vitro and cell-based thermal-shift assays showed that C1-27 induced a negative shift in the melting temperature indicating protein destabilization on binding (Supplementary Figs 11 and 15)

Other reports of mild side effects include lack of appetite, constipation, nausea, dry mouth, sweating, and anxiety/nervousness, but in placebo-controlled studies, these side effects occur at about the same incidence in the placebo groups