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Increased OXPHOS has shown to promote protein folding, mediating BTZ resistance (178)

Springer, Berlin, pp 6176 Abd Elhameed HA et al (2019) Purification of proteins with native terminal sequences using a Ni (II)-cleavable C-terminal hexahistidine affinity tag

This provides a molecular basis for the observed physiological effects, linking the in vitro findings to in vivo and clinical observations

Furthermore, it inhibits inflammatory cascades by suppressing the COX enzyme and prostaglandin E-2 (PGE2), also influencing various molecular signaling pathways related to inflammation, apoptosis, and oxidative stress, like PPAR, PI3K, TLR-4, Akt, mTOR, ERK5, AP-1, TGF-, PAK1, Wnt, -catenin, Shh, Rac1, p38MAPK, EBP, NLRP3 inflammasome, Nrf2, Notch-1, AMPK, STAT3, and MyD-88, crucial in IBD development [504]