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In preclinical research settings, NNMT modulation is investigated for its downstream influence on NAD + -related biochemical pathways and cellular energy regulation

Its an exciting time for personalized medicine, and I think WHIM is going to be a poster child for rare diseases and the ability where were at now in modern medicine to design therapies to treat underlying genetic disorders, Teresa Tarrant, an associate professor at Duke Universitys School of Medicine and lead investigator of the 4WHIM trial, told BioSpace prior to Xolremdis approval

Abbreviations 5-ASA: 5-aminosalicylic acid CAT: Catalase DAI: Disease activity index NK: Natural killer NSAIDs: Non-steroidal anti-inflammatory drugs ROS: Reactive oxygen species SCFAs: Short-chain fatty acids sIgA: Secretory immunoglobulin A SOD: Superoxide dismutase Th: T helper cells TJ: Tight junction TLR: Toll-like receptors TNF-: Tumor necrosis factor-alpha ZO: Zonula occludens References Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF

MacDonald, Jan