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USA 93: 3497-3502

10.1038/nature12820 28 DeGruttolaA

FIGURE 5 (A) Alignment of CopR repressors and (B) alignment of CopB proteins

Characterized by accumulation of amyloid-beta (A) plaque, neurofibrillary tangles (NFTs), and neurodegeneration, sporadic AD is understood to be the result of multiple genetic factors, as well as interactions between genes and environmental factors