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Associations of tissue tumor mutational burden and mutational status with clinical outcomes in KEYNOTE-042: pembrolizumab versus chemotherapy for advanced PD-L1-positive NSCLC

doi: 10.1016/j.drup.2011.03.001 167 RiceGCLingVSchimkeRT

4446 For example, in a Chinese study of 5840 patients with a recent ischaemic stroke or transient ischaemic attack receiving optimal preventive treatment, the subgroup with relatively high C-reactive protein (CRP) concentrations both at baseline and at 3-month of follow-up had significantly worse outcomes at 1 year when compared to the subgroup with relatively low CRP at both timepoints (stroke recurrence: adjusted hazard ratio, aHR = 1.39, 95% CI: 1.081.78, p = 0.01

These events trigger a series of pathological responses in the cytoplasm and nucleus of the cell, ultimately leading to cytoskeleton destruction and neuronal necrosis (Lai et al., 2014)