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Investigational agents involving the ISR in current ALS clinical trials target the eIF2 complex, PP1R15A, and pathological RAN translation (Table 3)

More long COVID patients had CD68 + macrophage infiltration in skeletal muscle compared to healthy controls (Fig

In general, the most frequently reported symptoms in cirrhosis include: pain (prevalence range 3079%), breathlessness (2088%), muscle cramps (5668%), sleep disturbance (insomnia 2677%, daytime sleepiness 29.571%), psychological symptoms (depression 4.564%, anxiety 1445%), and erectile dysfunction (5393%) in men (3, 4)