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Connexin43 (Cx43) is the most widely expressed connexin, and it is abundantly present on the apical protrusions of RMCs, which are involved in maintaining the vascular permeability of the retina and the structure of the BRB, as well as in regulating cell apoptosis ( 3.2.3 RMCs and growth factors Hyperglycemia promotes the secretion of growth factors, such as vascular endothelial growth factor (VEGF) (Schmalen et al., 2021), which are involved in the regulation of neovascularization and cause retinal fibrosis in DR

doi:10.1002/ibd.21082 3

In situations characterized by inflammation, specific cytokines, notably TNF-, IL-6, and IL-1, amplify leptin production by acting as potent stimulants for adipocyte activity

One great way to do so is by drinking plenty of water and eating a diet rich in fruits and vegetables both excellent detoxifiers