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[159] mixed Ce 3+ with the -cyclodextrin-engineered hyaluronic acid (HA) framework to form ultrasmall CeO x (35 nm) via the nucleation site of carboxylic groups, finally constructing spherical HA@RH-CeO X micelles with a diameter of 200 nm, which accurately targeted LPS-induced RAW264.7 cells and released Ce with SOD-like enzymatic activity to scavenge ROS, detected by flow cytometry and confocal laser scanning microscopy (CLSM), thus downregulating inflammatory signals to drive M2 repolarization for incomplete Freunds adjuvant (IFA)/collagen-induced RA mice therapy, measured by RT-qPCR, WB, CLSM, and immunofluorescence staining

Acknowledgments The authors would like to express their sincere gratitude to Ilya Raskin for granting permission to reproduce Figure 2 in this article