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These include the quadriceps group, especially the vastus medialis and vastus lateralis, as well as the hamstrings, gastrocnemius, popliteus, and even the hip muscles such as the gluteus medius and hip adductors

Eur Heart J 2011

This interaction promotes fibroblast activation and proliferation [105] and upregulates the expression of pro-fibrotic markers -SMA, desmin, fibronectin, and collagen I [6, 103] (Fig

Intriguingly, PIK3C3/VPS34 lactylation augments its interaction with Beclin1, Atg14L, and UVRAG, increasing its lipid kinase activity and promoting macroautophagy/autophagy and endolysosomal degradation