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Highly toxic contaminants such as mercury originating from gold mining and coal combustion and polychlorinated biphenyls (PCBs) from industrial sources bioaccumulate in aquatic organisms, leading to endocrine disruption, altered circadian rhythms, and reproductive toxicity [104, 105]

Selectivity was predominantly observed in positions 1 to +3 relative to the phosphoacceptor Tyr (Extended Data Fig

The most commonly used DMARDs are: METHOTREXATE ( Non-Biologic ): it can be taken orally, has antiinflammatory effects and reduces the number of activated T cells and TNF- levels

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