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Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109

This Research Topic aims to highlight recent advancements and challenges in MS-based adductomics within biological matrices, and further adductomic approaches to the study of the exposome in health and disease

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