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Description

We screened a pooled lentiviral library targeting 18,205 human genes

Mice were bred and maintained at the Lockey preclinical research facility of the Weizmann Institute of Science

Ubiquitin-linked mutant huntingtin has been found in neuronal intranuclear inclusions and dystrophic neurites in the cortex and striatum of HD patients (Difiglia et al., 1997)