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Inhibiting PFKFB3 activity in an in vitro IR model blocks glycolytic activation, forcing neurons to switch to the PPP metabolic pathway, thereby realizing a neuroprotective effect (54)

10.1038/sdata.2016.18 61 YangL.WangX.LiuJ.LiuX.LiS.ZhengF.et al (2023)

Journal of Cosmetic Dermatology 14(2):83-90. [doi.org]

Experiments were carried out C6 astroglioma cells, a cellular model which recapitulates astrocytes features ( We found here that in C6 cells GSH depletion exacerbates store-operated calcium entry (SOCE) mechanism triggered by IP 3 -mediated Ca 2+ release