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The microbial metabolite itaconate reduces Th17 differentiation and promotes Treg generation by inhibiting both glycolysis and OXPHOS (173)

For all PEA doses there is an increase in negative volume of activation over vehicle

The flow rate was kept at 300 l min 1 and gradient was as follows: 0 min 80% of B, 12 min 50% of B, 26 min 50% of B, 28 min 20% of B, 36 min 20% of B, 3745 min 80% of B