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doi: 10.1016/j.bbagen.2017.05.019 41 LuoLLiuKDengLWangWLaiTLiXet al

Dihydroartemisinin has been demonstrated to modulate cytotoxic T lymphocyte (CTL) function by influencing Treg cell inhibition, thereby enhancing anti-cancer immunity in mice and inhibiting the growth of melanoma (B16-F10) cells [172, 173]

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Similar to these studies, there are studies in which vitamin C (Reference Savran, Cicek and Doguc7) , resveratrol (Reference zgmen and Yeilot44) , quercetin (Reference Yuksel, Yuksel and Yagmurca45) , berberine (Reference Mehrzadi, Fatemi and Esmaeilizadeh48) and gallic acid (Reference Olayinka, Ore and Adeyemo43) were used to treat MTX-induced tissue damage