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Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability

Oxidative stress and docosahexaenoic acid injury-induced downregulation of ferroptosis regulator acyl-CoA synthetase long-chain family member 4 (ACSL4), increased lipid peroxidation and decreased cell viability, and lead to ferroptosis in RPE (Neiteler et al., 2023)

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Adjustments to dosage may be necessary based on individual response and any potential side effects