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[DOI] [PubMed] [Google Scholar] 165.Li J., Jiang X., Shang L., Li Z., Yang C., Luo Y., Hu D., Shen Y., Zhang Z

Characterization of the dual functional effects of heat shock proteins (Hsps) in cancer hallmarks to aid development of hsp inhibitors

It is the single most protective antioxidant produced by the body and therefore the most important, as it protects cells against oxidative stress from free radicals

Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)