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Another study, however, showed senescence-associated decline in HUVEC glycolysis, which was reversed by overexpressing nuclear factor erythroid 2-related factor 2 48

Then there are FABPs, FABPs are a class of low molecular weight intracellular proteins that bind efficiently to bilirubin (176) and deliver it to the PPAR in the nucleus (177), and this delivering action contributes to bilirubins binding to and functioning on the PPAR

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This biphasic nature positions the NO signaling pathway as a sophisticated, druggable node in the regulation of CRC cell death