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USA 110 , E736E745 (2013)

Free radicals can damage renal tubular cells and disrupt the function of sodium transporters, leading to sodium retention and increased blood volume, which further elevates blood pressure [82]

This then influences the expression of cytokines and other pro-inflammatory mediators, including inducible nitric oxide synthase and cyclooxygenase-2, thereby contributing to the inflammatory response in hepatic tissue (34)