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[32] Ashizawa, Tatsuto, et al

Dermal fibroblasts are reduced in number [17, 21] and functionally altered producing more matrix metalloproteinases (MMPs) and less extracellular matrix proteins [21, 22]

For the sake of discussion in this paper, we will be focusing on these aforementioned pathways as they are most significantly upregulated or downregulated in GBMs

The multicentre, randomized, double-blind, placebo-controlled ALADIN III trial demonstrated significant improvement in the Neuropathy Impairment Score (NIS) in patients who received -lipoic acid but no significant improvement in the Total Symptom Score (TSS) 176