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pH of the medium should also be carefully selected to cater to the need as per the pH of the drug formulation, pH solubility profile of the active and also pH of the target membrane

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Moreover, due to the positive charge of the N -alkylpyridinium group, the corresponding bioconjugation reagents reveal lower partition coefficients (Octan-1-ol to water, cLog P o/w ), in comparison to other known reagents (Supplementary Fig