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In vivo assessments demonstrated that AANLCs significantly reduced tumor volume (3.30 0.23 cm 3 ) and weight (5.37 0.41 g), enhanced cytotoxicity (92.36%), and improved survival outcomes (49.66 days), compared to the free drug administered as suspension (0.25%w/v Na-CMC) (42 days)

For the cases 2 and 3, when different doses of APAP ingestion simultaneously along with alcohol ingestion and when alcohol is ingested within a range of one to seven days after APAP is ingested, the initial condition for C is set to the no damaged state and the initial conditions for other variables are given by 11 to numerically track minimum hepatocyte level for different range of alcohol and APAP intake