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doi: 10.1155/2012/925135 150 MacintyreANGerrietsVANicholsAGMichalekRDRudolphMCDeoliveiraDet al

Oxford: Hart Publishing, pp

For example, Adrian Bird defined epigenetics as "the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states." [6] This definition would be inclusive of transient modifications associated with DNA repair or cell-cycle phases as well as stable changes maintained across multiple cell generations, but exclude others such as templating of membrane architecture and prions unless they impinge on chromosome function