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Kiefer JD, Myburgh R, Russkamp NF, Volta L, Guggisberg A, Abdelmotaleb O, et al

HuR/p38/MK2 Signaling Pathway In experimental studies in a mouse model of intraperitoneal transduction of HuR-RNAi lentivirus, suppression of HuR gene expression in mouse POI was shown to cause a significant reduction in inflammation (in infiltration of inflammatory cells, expression of pro-inflammatory genes, and reduction in serum cytokines) via the p38/MK2 signaling pathway (Xiong et al., 2017)