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Goldman JD, White DG, Levy SB

By maintaining a strong presence in the intestinal lumen, charcoal acts as a sink for toxins excreted in the bile

doi: 10.1248/bpb.33.598

286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction