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On the other hand, if uncontrolled, the enormous increase in the ROS levels inserts negative oxidative influences on cellular proteins, lipids and nucleic acid, ultimately leading the affected cell towards controlled programmed cell death (PCD) [89]

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Karan Lal, DO, FAAD, a double board-certified cosmetic and pediatric dermatologist at Affiliated Dermatology in Scottsdale, Arizona

95 Essentially, the rationale for the latest immunotherapeutic agents is to reverse the inhibition of tumor cell-mediated T-cell responses, thereby providing a boost to the immunocytes as they confront MM cells containing innumerable mutations, generating epitopes ripe for recognition by the patients innate and adaptive immunocytes