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Based on Autism cases identified from 1990 through 2006 in databases of the California Department of Developmental Services

The process begins in the stratum basale, the deepest layer of the epidermis, where stem cells and progenitor cells are constantly dividing through mitosis

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These processes are central to the pathogenesis of a wide range of NDDs, including Alzheimers disease (AD), Parkinsons disease (PD), primary tauopathies (e.g., progressive supranuclear palsy [PSP], corticobasal degeneration [CBD], tau-linked frontotemporal dementia [FTD-tau]), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), synucleinopathies (e.g., Lewy body dementia [LBD] and multiple system atrophy [MSA]), Huntingtons disease (HD) and related polyglutamine (polyQ) diseases (e.g., spinocerebellar ataxias [SCA]), and prion diseases (PrD)