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Higher Doses: Some individuals, under professional supervision, may explore doses up to 20 mg or more, but this increases the risk of unknown side effects

Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation