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PubMed Central , Killian, et al

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When erythrocytes are incubated in autologous plasma rather than an individual substrate, lactate production should reflect the potential rate of production in vivo whereas incubation with an individual substrate should help to define which compounds may be contributing to lactate production in vivo

Though precisely how RagA/B-mTORC1 senses cyst(e)ine levels and how mTORC1 specifically regulates GPX4 protein synthesis remain to be fully characterized