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The hypothalamus modulates pulsatile gonadotropin-releasing hormone (GnRH) secretion, which governs pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)

Synthetic OSC derivatives and efflux/anti-biofilm activity - Recent medicinal chemistry work on stabilized sulfonyl and sulfoxide analogues shows promising in vitro potency against multidrug-resistant strains, with activity against efflux systems and biofilms in vitro and in select animal models

Gluten, a protein found in wheat, rye, and barley, has been associated with intestinal permeability, especially among those who have gluten intolerance

In moderate to severe TBI the signaling pathways become more complicated, and there are many potential pathways that can be targeted and blocked for therapeutic intervention like IL-6, TNFa, TLRs, S100 (DAMPs), RAGE, JAK2/STAT3, and/or VEGF/MET to prevent neuroglial overactivation, neuroinflammation, gliosis, loss of inhibition, synaptic knock-down, cell death, and chemokine secretion, and we hope to conduct further research on these conditions (2a)