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[1] In practice, 1 mL (which provides the full 100 mg of B and B, etc.) is a common dose for general supplementation in deficient states, but clinicians may start with lower volumes for mild deficiencies or in smaller patients

Int J Mol Med

Nicotinamide N-methyltransferase as a potential therapeutic target in metabolic and related diseases

Initial correction of significant deficiency typically involves weekly or biweekly injections for several weeks until levels normalize and symptoms resolve