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These findings underscore the importance of mitochondrial health in disc homeostasis and provide novel insights into precise strategies for treating age-related degenerative spinal diseases

Acknowledgements We are thankful to the anonymous reviewers who helped improve this paper

The results, tracked via proton magnetic resonance spectroscopy, were highly promising: the NAC supplementation successfully returned cortical glutathione, ventricular lactate, and oxidative stress levels back to normal, which correlated directly with a significant reduction in patient fatigue

Six mice were randomly divided into 2 groups and injected into the tail vein with Ru(II)-OH and NP4, respectively, and 10 L of blood was collected from the tail tip at 5 min, 10 min, 20 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, and 48 h