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In particular, an RCT including 108 diabetic patients with mildmoderate ED demonstrated that a daily treatment with 5 g l-ARG plus 10 mg tadalafil, administered for 8 weeks, significantly improved ED assessed by IIEF-5 and testosterone levels, with a more significant improvement in both endpoints compared to patients receiving tadalafil or l-ARG as single compounds, whereas the significant improvements at basal and dynamic PDU were similar between groups [16]

Fluoroquinolones and cardiovascular risk: A systematic review, meta-analysis and network meta-analysis

15 Similarly, Rong et al found that curcumin (75 mg/kg/day for six weeks) reduced ROS accumulation and counteracted lipid peroxidation in ALD