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Additional sampling was carried out on Ab DPcob using three parallel simulations as follows: 50 1 ns cycles of simulated annealing (700 ps at 300 K, 100 ps heating to 400 ps, 100 ps at 400 K, 100 cooling to 300 K) followed by an additional 350 ns of MD for each run, which was then used for analysis

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Nitric oxide release in turn supports vasodilation, which has been proposed as a contributor to the perfusion-related findings in tissue-injury models