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MiD49 and MiD51 are chordate-specific mitochondrial elongation factor proteins, both of which can recruit Drp1 to the mitochondrial fission site independently of Fis1 and Mff and can also coordinate with Mff to regulate Drp1-mediated mitochondrial fission (Yu et al., 2017)

Extending beyond 14 days does not appear to meaningfully extend therapeutic duration in most models

If larger trials confirm the early results, CagriSema may offer deeper weight loss for people who previously struggled on single-agent therapies

The cost difference between running both is modest relative to the complementary mechanistic coverage