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4.4 Huntingtons disease 4.4.1 Pathogenesis of HD Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances, which typically manifests in mid-adulthood with an average age of 3050 years old (Ling et al., 2025

Furthermore, medium and high concentrations of BHB could antagonize diabetic nephropathy injury, potentially by causing H3K9bhb to promote the generation of MMP-2 in diabetic rats (64)

It has been reported that interstitial space connection between cancer cells and matrix cells might underpin tumor proliferation and chemoresistance