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The neuroprotective action of IHT might be associated with generation of reactive oxygen species which in turn activate an extensive defense program, including nuclear factor erythroid 2-related factor 2 (Nrf2)a transcriptional factor regulating expression of genes encoding numerous phase II defense enzymes that collectively afford powerful antioxidant and anti-inflammatory cytoprotection (Dringen et al., 2015)

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Androgens Testosterone levels should be in the range of 0.5 3.5 nmol/L and are usually high with PCOS