dihexa clinical trial humans CAPSULES dihexa clinical trials dihexa human

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274 Donepezil is an acetylcholinesterase inhibitor that promotes the activation of AMPK and inhibits the activation of the NF-B pathway by facilitating the expression of low-density lipoprotein receptor-associated protein 1, thereby reducing inflammation and intestinal epithelial apoptosis in the colon

While most of the drug is conjugated via glucuronidation and sulfation, a small fraction is oxidised by cytochrome P450 enzymes especially CYP2E1 into N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive and hepatotoxic compound

I cannot tolerate antidepressants for some reason due to my stomach issues and I am also scared of them as they are hard to wean off