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On this note, a study of Pakistani patients with coronary heart disease and Type II diabetes found that the C allele was significantly associated with markers of oxidative stress and damage to arterial lining (vascular endothelial dysfunction)

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.McGuire L., Heffner K., Glaser R., Needleman B., Malarkey W., Dickinson S., Lemeshow S., Cook C., Muscarella P., Melvin W.S., et al

But whenever Sinclair brings up senolytics, he usually mentions both fisetin and quercetin, both of which are potent anti-inflammatory plant-based compounds (polyphenols) that significantly reduce senescent cells in preclinical studies