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Taken together, it is important to realize that at present no animal model represents the full clinical situation perfectly because of interspecies differences and inevitable differences between the conditions created in animals and those observed in human CIPN

However, studies showing that SnPP is a photosensitizer of bilirubin destruction in vitro (McDonagh and Palma, 1985), and phototoxic in vivo (Hintz et al., 1990) led to its abandonment for use in human infants

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Potential benefits suggested in studies include: binding certain metals in the digestive tract antioxidant support