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Yes, using a phone can contribute to dark circles due to eye strain and blue light exposure, which causes blood vessels to dilate and become more visible

Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice

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Published studies primarily focus on its interaction with enzymatic and metabolic pathways rather than endocrine signaling systems