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The proportion of subjects becoming non-self-sufficient after 12 months of follow-up, defined as those scoring 2 or lower on at least one of the ALSFRS-R items for swallowing, and/or cutting food and/or handling utensils, or walking, in subjects treated with ALCAR 3 g/day and not treated subjects

These lipids typically constitute a very small proportion ( 20 kJmol 1 68,69 ) resulting in timescales on the order of hours to weeks

BDNF is widely expressed in neurons, astrocytes, and microglia, among which microglia are regarded as the primary source of BDNF (162)

cinerea , which was supposed to contribute to the chemical stress tolerance of the fungus