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These variations influence the balance between different network activities, leading to altered responses in the salience, visual, internal reward, and executive control networks, thereby highlighting the complex interplay between DA, reward network dysregulation, and the manifestation of depressive symptoms in CID patients (Gong et al., 2023)

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50,51 Notably, DMT1 has also been implicated in the uptake of copper (I), potentially serving as a compensatory mechanism in the absence of CTR1