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6 This suggests that glutathiones antioxidative properties can directly interfere with the viral life cycle, potentially reducing the severity and duration of cold sore outbreaks

doi: 10.1128/mBio.00264-13 35 De BockM.Van HaverV.VandenbrouckeR

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However, this is considered an underestimation as it will be unlikely to be detected in smaller clinical trials, and a more recent study in 2010 found that NSAIDs including ibuprofen (odds ratio of 2.24, 95% confidence interval (CI) = 1.992.52) increased the risk of hospitalization due to acute hepatitis (odds ratio 2.13, 95% CI = 22.18) 35