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Sliter et al

Keep expectations measured

Therefore, to establish a realistic and efficient workflow for unknown biological samples, a representative pooled sample was first analyzed in a qualitative screening run to estimate the baseline concentrations of all analytes

Targeted inhibition of PTDSS1 expression results in increased ubiquitination of SLC3A2 and inhibition of GSH synthesis, thereby inducing oxidative stress in tumor cells, activating the PINK1/Parkin/MFN2 mitophagy pathway, and ultimately promoting tumor cell apoptosis and ferroptosis (Fig