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In contrast, NOX 4 plays important roles in endogenous detoxification reactions, angiogenesis, ERS, substrate utilization, and stress responses (40)

Peptides that can cross the BBB include the following examples: Peptide Drugs that Can Cross the B BB Leuprorelin: Leuprorelin is a GnRH agonist peptide drug used to treat various hormone-related conditions such as prostate cancer and endometriosis

In cellular models, GSH depletion increases neuronal death in striatal neurons expressing mHTT, reinforcing the role of GSH-dependent redox imbalance in HD progression (400)

Commonly noted side effects include fluid retention, numbness in the hands or feet, and increased feelings of tiredness