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Since activation of cMyc expression via CRISPRa as well as cMyc T58A expression was sufficient to sensitize SCLC cells to ferroptosis in our experiments, it is tempting to speculate whether NOTCH pathway activation by cMyc might be responsible for this

Ferroptosis subtypes, TME subtypes, ANPY subtypes, tumor stage, neuroendocrine state, age, and gender were used as patient annotations in the public cohort ( Figure 6A )