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The possible function of SULTR1;2 (Zhang et al., 2014) as a sulfate sensor is intriguing, particularly as the Chlamydomonas regulator of S-starvation response, SAC1, is similar to SULTR of the SLC13 group (Takahashi et al., 2011a)

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NAD + degradation NAD + consumption As a co-substrate important to various postsynthesis modifications of fundamental macromolecules, NAD + can be cleaved by NAD + -consuming enzymes including PARPs, sirtuins, CD38 and SARM1 to generate NAM and ADP-ribose (ADPR) (Fig